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Kouhunin was a synthetic neurotoxin based on the venom of kouhuns.

Darth Vader was injected with a highly diluted amount of kouhunin in order to suppress the intense pain that he underwent after the Duel on Mustafar. It was distributed to his body via a chemical injector and cartridge located just below his right collarbone. This cartridge could be accessed through a small gasket in the bodysuit.

Even as Vader's body possessed this substance, he remained in constant torment.

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